Deciphering Important Mechanisms That Lead to Cerebral Palsy and Related Disorders

Primary NeuronThe Department of Child Health Molecular and Cellular Neurogenetics Laboratory seeks to overcome current limitations in our ability to effectively diagnose and treat children with neurodevelopmental and neurodegenerative disorders that affect movement.

Our work seeks answers to critical questions that impact the health of young people. Our program is inherently translational, with research projects often stemming from encounters with children and adolescents treated at the Phoenix Children’s Hospital Pediatric Movement Disorders Program.

Objectives:

  • Define the molecular basis of pediatric movement disorders, including inherited spasticity, dystonia, chorea, ataxia and parkinsonism.
  • Discover crucial mechanisms of disease that result from dysfunction of basic cellular pathways that regulate the dynamic cytoskeleton and the autophagy-lysosome pathway.
  • Develop informative in vitro systems and animal models to test targeted therapies.

For further information, please contact the Molecular and Cellular Neurogenetics laboratory principal investigator Dr. Michael Kruer or visit our lab web site.