Contact Info

Phone:
602-827-2142
Fax #:
602-827-2130

Assistant Professor

Faculty
College of Medicine Phx Basic Medical Sciences

Education

  • PhD: North Carolina State University at Raleigh.

Publications

  • Maatough A, Whitfield GK, Brook L, Hsieh D, Palade P, Hsieh JC. Human Hairless Protein Roles in Skin/Hair and Emerging Connections to Brain and Other Cancers.  J Cell Biochem. 2017 May 23. PMID: 28543886. [Epub ahead of print].
  • Kollitz EM, Zhang G, Hawkins MB, Whitfield GK, Reif DM, Kullman SW. Evolutionary and Functional Diversification of the Vitamin D Receptor-Lithocholic Acid Partnership. PLoS One. 2016 Dec 12;11(12):e0168278. PubMed PMID: 27942020
  • Haussler MR, Whitfield GK, Haussler CA, Sabir MS, Khan Z, Sandoval R, Jurutka PW. 1,25-Dihydroxyvitamin D and Klotho: A Tale of Two Renal Hormones Coming of Age. Vitam Horm. 2016;100:165-230. PMID: 26827953
  • Kaneko I, Saini RK, Griffin KP, Whitfield GK, Haussler MR, Jurutka PW. FGF23 gene regulation by 1,25-dihydroxyvitamin D: opposing effects in adipocytes and osteocytes. J Endocrinol. 2015 Sep;226(3):155-66.                       
  • Dampf Stone A, Batie SF, Sabir MS, Jacobs ET, Lee JH, Whitfield GK, Haussler MR, Jurutka PW. Resveratrol potentiates vitamin D and nuclear receptor signaling. J Cell Biochem. 2015 Jun;116(6):1130-43. doi: 10.1002/jcb.25070. PubMed PMID: 25536521

For a complete listing of Dr. Whitfield's publications, search PubMed.

Research Interests

Vitamin D receptor, psoriasis, lipophilic ligands

Research Summary

Research by Dr. Whitfield focuses on elucidating the role of the mammalian vitamin D receptor (VDR) in treating psoriasis, for which VDR ligands are an approved therapy. In addition to 1,25-dihydroxyvitamin D (1,25D), other compounds under investigation include delphinidin, cyanidin and resveratrol. Identifying which psoriasis-relevant genes are regulated by VDR in skin could lead to superior agents to treat mild/moderate psoriasis for which there is currently no satisfactory therapy.