Dr. Peter Wesley Jurutka, PhD head shot

Contact Info

Building
AHSC
Room Number
425
Professor
DCC
College of Medicine Phx Basic Medical Sciences

Brief Bio

Lab Website

Education

  • PhD: The University of Arizona.

Publications

  • Xu H, Wang Y, Zhao J, Jurutka PW, Huang D, Liu L, Zhang L, Wang S, Chen Y and Cheng S. Triterpenes from Poria cocos are revealed as potential retinoid X receptor selective agonists based on cell and in silico evidence. Chemical Biology and Drug Design, 2020, 95:493-502. https://doi.org/10.1111/cbdd.13610.
  • Jurutka PW and Wagner CE. Methods to assess activity and potency of rexinoids using rapid luciferase-based Assays: A case study with NEt-TMN. Methods Mol Biol., 2019:95-108. https://doi.org/10.1007/978-1-4939-9585-1_7.
  • Zhang D, Leal AS, Carapellucci S, Shahani PH, Bhogal JS, Ibrahim S, Raban S, Jurutka PW, Marshall PA, Sporn MB, Wagner CE and Liby KT. Testing novel pyrimidinyl rexinoids: A new paradigm for evaluating rexinoids for cancer prevention. Cancer Prevention Research, 2019, 12:211-224.  https://doi.org/10.1158/1940-6207.CAPR-18-0317.
  • Sabir MS, Haussler MR, Mallick S, Kaneko I, Lucas DA, Haussler CA, Whitfield GK and Jurutka PW. Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neuronal cell lines. Genes and Nutrition, 2019, 13:19-30. https://doi.org/10.1186/s12263-018-0605-7.
  • Dussik CM, Hockley M, Grozic A, Kaneko I, Zhang L, Sabir MS, Park J, Wang J, Nickerson CA, Yale SH, Rall CJ, Foxx-Orenstein AE, Borror CM, Sandrin TR and Jurutka PW. Gene expression profiling and assessment of vitamin D and serotonin pathway variations in patients with irritable bowel syndrome. Journal of Neurogastroenterology and Motility, 2018, 24:96-106. http://dx.doi.org/10.5056/jnm17021.

For a complete listing of Dr. Jurutka's publications, search PubMed.

Research Interests

Cancer, nutraceuticals, healthy aging

Research Summary

The Jurutka laboratory applies molecular medicine approaches to elucidate fundamental questions in human health and disease, including: 1. mechanistic effects of "nutraceuticals" on anti-aging gene expression and chemoprevention, 2. elucidation of genetic "fingerprints" for diagnosis/treatment of irritable bowel syndrome, 3. rexinoid drug design/discovery to develop pharmaceuticals for treatment of cancer and Alzheimer’s disease and 4. neurobiology of vitamin D action in autism and depression.