Salvatore Oddo, PhD head shot

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Associate Professor

College of Medicine Phx Basic Medical Sciences


  • PhD: Neurobiology and Behavior, University of California Irvine, 2005


  • Branca C, Ferreira E, Nguyen TV, Doyle K, Caccamo A, Oddo S. Genetic reduction of Nrf2 exacerbates cognitive deficits in a mouse model of Alzheimer's disease. Hum Mol Genet. 2017 Dec 15;26(24):4823-4835.
  • Caccamo A, Branca C, Piras IS, Ferreira E, Huentelman MJ, Liang WS, Readhead B, Dudley JT, Spangenberg EE, Green KN, Belfiore R, Winslow W, Oddo S. Necroptosis activation in Alzheimer’s disease. Nature Neuroscience. 2017, Sep;20(9):1236-1246.
  • Velazquez A, Tran A, Ishimwe E, Denner L, Dave N, Oddo S*, Dineley KT*. Central insulin dysregulation and energy dyshomeostasis in two models of Alzheimer’s disease. Neurobiol Aging. 2017 Oct;58:1-13.
  • Branca C, Shaw DM, Belfiore R, Gokhale V, Shaw AY, Foley C, Smith B, Hulme C, Dunckley T, Meechoovet B, Caccamo A and Oddo S. Dyrk1 inhibition improves Alzheimer’s disease-like pathology. Aging Cell. 2017 Oct;16(5):1146-1154.
  • Branca C and Oddo S. Paving the way for new clinical trials for Alzheimer’s disease. Biological Psychiatry. 2017 Jan 15;81(2):88-89.

*Co-senior authors

Research Interests

Alzheimer’s disease, neurodegeneration, aging, cognition

Research Summary

Dr. Oddo’s research focuses on understanding the molecular mechanisms underlying memory deficits in Alzheimer’s disease. Using animal models, he showed that dysfunction signaling transduction pathways that are critical for learning and memory play a pivotal role in the cognitive decline associated with Alzheimer’s disease. Currently, he is the principal investigator of multiple grants, which is focused on elucidating key mechanisms involved in the pathogenesis of Alzheimer’s. Dr. Oddo has published more than 80 research articles in international peer-reviewed journals.