Contact Info

Phone:
520-626-7692
Fax #:
602-406-7172

Professor

DCC
College of Medicine Phx Basic Medical Sciences

Education

  • Postdoctoral: Tohoku University School of Medicine, 1994 – 1996.
  • Postdoctoral: University of New Mexico School of Medicine, 1993 – 1994.
  • PhD: Sun Yat-Sen University of Medical Sciences, China, 1990.
  • MD: Xuzhou Medical College, China, 1983.

Publications

  • Wu J*, Liu Q, Tang P, Mikkelsen JD, Shen J, Whiteaker P, Yakel JL. Heteromeric α7β2 Nicotinic Acetylcholine Receptors in the Brain. Trends Pharmacol Sci. 2016 Jul;37(7):562-74. PMID: 27179601
  • Zhang HY, Gao M, Liu QR, Bi GH, Li X, Yang HJ, Gardner EL, Wu J*, Xi ZX*. Cannabinoid CB2 receptors modulate midbrain dopamine neuronal activity and dopamine-related behavior in mice. Proc Natl Acad Sci USA. 2014 Nov 18;111(46):E5007-15. PMID: 25368177
  • Liu Q, Xie X, Lukas RJ, St John PA, Wu J*. A novel nicotinic mechanism underlies β-amyloid-induced neuronal hyperexcitation. J Neurosci. 2013 Apr 24;33(17):7253-63. PMID: 23616534
  • Zhang D, Gao M, Xu D, Shi WX, Gutkin BS, Steffensen SC, Lukas RJ, Wu J*. Impact of prefrontal cortex in nicotine-induced excitation of ventral tegmental area dopamine neurons in anesthetized rats. J Neurosci. 2012 Sep 5;32(36):12366-75. PMID: 22956827
  • Yang K, Buhlman L, Khan GM, Nichols RA, Jin G, McIntosh JM, Whiteaker P, Lukas RJ, Wu J*.Functional nicotinic acetylcholine receptors containing α6 subunits are on GABAergic neuronal boutons adherent to ventral tegmental area dopamine neurons. J Neurosci. 2011 Feb 16;31(7):2537-48. PMID: 21325521

For a complete listing of Dr. Wu's publications, search PubMed.

Research Interests

Nicotine receptors, epilepsy, neurodegenerative diseases, nicotinic acetylcholine receptor physiology, pharmacology and pathophysiology, epileptogenetic mechanisms, neuro-degenerative and psychiatric disease

Research Summary

The research projects in Dr. Wu’s lab have two directions: 1.) Study of physiology, pharmacology and pathophysiology of neuronal nicotinic acetylcholine receptors (nAChR). 2.) Study the epileptogenesis using human gelastic seizures tissues and also animal models. Electrophysiological techniques (single cells, slices and in vivo recordings) are major approaches for his study. He has used his experience as an electrophysiologist to make significant contributions to these research fields. Thus far, Dr. Wu’s lab has published more than 150 peer reviewed articles with a total citation of 3,351, h-index 34 and i10-index 88.