Contact Info

Phone:
602-406-8685
Fax #:
602-406-6459

Associate Professor

DCC
College of Medicine Phx Basic Medical Sciences

Lab Website

Publications

  • Zhang PW, Haidet-Phillips AM, Pham JT, Lee Y, Huo Y, Tienari PJ, Maragakis NJ, Sattler R*, Rothstein JD*. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia 2016 Volume 64, Issue 1, pages 63–75. doi: 10.1002/glia.22903
  • Ghosh M, Lane M, Krizman E, Sattler R, Rothstein JD, Robinson MB. Transcription Factor Pax6 Contributes to Induction of GLT-1 Expression in Astrocytes Through an Interaction with a Distal Enhancer Element. J Neurochem. 2015 Oct 20. doi: 10.1111/jnc.13406
  • Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, Ostrow LW, Matunis MJ, Wang J, Sattler R, Lloyd TE, Rothstein JD. The C9ORF72 repeat expansion disrupts nucleocytoplasmic transport. Nature 2015 Sep 3;525(7567):56-61. doi: 10.1038/nature14973.
  • Thomas AG, Sattler R, Tendyke K, Loiacono KA, Hansen H, Sahni V, Hashizume Y, Rojas C, Slusher BS. High-Throughput Assay Development for Cystine-Glutamate Antiporter (xc-) Highlights Faster Cystine Uptake than Glutamate Release in Glioma Cells. PLoS One. 2015 Aug 7;10(8):e0127785. doi: 10.1371/journal.pone.0127785
  • Li Y, Balasubramanian U, Cohen D, Zhang PW, Mosmiller E, Sattler R, Maragakis NJ, Rothstein JD. A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells. PLOS ONE 2015 Mar 11:10(3):e0118266

*Co-corresponding senior authors

Research Interests

ALS, iPSC, neurodegeneration

Research Summary

The Sattler laboratory studies cellular and molecular mechanisms of neurodegeneration in CNS disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) with a particular interest in the role of synaptic dysfunction. We utilize different disease models including patient-derived human induced pluripotent stem cells, patient autopsy brain tissue and animal models of disease and employ state of the art molecular, biochemical and microscopy technologies.