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University of Arizona College of Medicine - Phoenix 475 North 5th Street, Phoenix, AZ 85004
Director, Molecular Analysis Core
Assistant Research Professor, Research Series - Internal Medicine
Assistant Research Professor, Research Series - Dermatology
Director, Molecular Analysis Core - Research
Faculty
Internal Medicine; Dermatology; Research
Education
- Postdoctoral Fellowship: University of Arizona, 2017
- PhD: Molecular Pharmacology & Cancer Therapeutics, Roswell Park Cancer Institute, 2016
Publications
- Stahl E, Nott R, Koessel K, Cance W & Marlowe T (2020). Computational-based discovery of FAK FERM domain chemical probes that inhibit HER2-FAK cancer signaling. Chemical Biology & Drug Design., 02/20/2020 - Article, Refereed Journal -
- Alvarado C, Stahl E, Koessel K, Rivera A, Cherry B, Pulavarti SV, Szyperski T, Cance WG & Marlowe T (2019). Development of a fragment-based screening assay for the focal adhesion targeting domain using SPR and NMR. Molecules. Molecules. Vol. 24(18), 09/14/2019 - Article, Refereed Journal -
- Marlowe T, Alvarado C, Rivera A, Lenzo F, Nott R, Bondugji D, Montoya J, Hurley A, Kaplan M, Capaldi A & Cance WG (2019). Development of a high-throughput fluorescence polarization assay to detect inhibitors of FAK-Paxillin binding. SLAS Discovery., 09/12/2019 - Article, Refereed Journal -
- Marlowe T, Lenzo F, Figel S, Grapes A & Cance WG (2016). Oncogenic Receptor Tyrosine Kinases Directly Phosphorylate Focal Adhesion Kinase (FAK) as a Resistance Mechanism to FAK-Kinase Inhibitors. Molecular Cancer Therapeutics., 12/2016 - Article, Refereed Journal -
- Cance WG, Kurenova E, Marlowe T & Golubovskaya V (2013). Disrupting the Scaffold to Improve Focal Adhesion Kinase-Targeted Cancer Therapeutics. Science Signaling., 03/26/2013 - Article, Refereed Journal -
Research Interests
- Therapeutic Discovery - Focal Adhesion Kinase - Anticancer Drug Discovery