Mitra Esfandiarei


Midwestern University 19555 North 59th Avenue, Glendale, AZ 85308
Associate Research Professor, Research Series
Associate Research Professor, Research Series - Basic Medical Sciences
Basic Medical Sciences


  • Postdoctoral Fellowship: BC Children's Hospital Research Institute, 2010
  • PhD: Pathology and Laboratory Medicine, University of British Columbia, 2006


  • White Z, Milad Nadia, Tehrani AY, Lamothe J, Hogg JC, Esfandiarei M, Seidman M, Booth S, Hackett TL, Morissette MC & Bernatchez P (2019). Sildenafil prevents Marfan-associated emphysema and early pulmonary artery dilation in mice. Am J Pathol. Vol. 189(8), 1536-1546., 08/2019 - Article, Refereed Journal -
  • Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Loapschuk GD & Broderick TL (2019). Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease. Drug Des Devel Ther. Vol. 13, 1197-1211., 04/17/2019 - Article, Refereed Journal -
  • Cui JZ, Lee L, Sheng X, Chu F, Gibson CP, Aydinian T, Walker DC, Sandor GGS, Bernatchez P, Tibbits GF, van Breemen C & Esfandiarei M (2019). In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm. Sci Rep. Vol. 9(1), 2071., 02/14/2019 - Article, Refereed Journal -
  • Sellers S, Milad N, Chan R, Mielnik M, Jermilova U, Huang PL, de Crom R, Hirota J, Hogg JC, Sondor GG, van Breemen C, Esfandiarei M, Seidman M & Bernatchez P (2018). Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan: Role of ATR1-Independent Activation of Endothelial Function. Am J Pathol. Vol. 183(3), 03/2018 - Article, Refereed Journal -
  • Gibson C, Alex R, Cooper K, Cui JZ, Gaufin D, Farney M, Broderick T, van Breemen C, Vallejo-Elias J & Esfandiarei M (2017). Structural and functional effects of mild exercise on the progression of aortic aneurysm in a mouse model of Marfan syndrome. J Appl Physiol. Vol. 123(1), 147-160., 07/01/2017 - Article, Refereed Journal -
Research Interests
- Aortic Aneurysm - Vascular Complications in Alzheimer's Disease - Vascular Dysfunction in Traumatic Brain Injury - Calcium Signaling - Endoplasmic Reticulum Stress Response
Research Summary
Dr. Esfandiarei’s Laboratory is interested in understanding the pathological events underlying the initiation and progression of aortic aneurysm using a genetic animal model of aortic aneurysm and in human patients. Her research also expands to investigating functional and structural changes within the wall of blood vessels that can contribute to the development of plaque formation or the severity of brain damage in well-established animal models of Alzheimer’s disease and traumatic brain injury