Associate Research Professor, Research Series
Associate Research Professor, Research Series - Basic Medical Sciences
Faculty
Basic Medical Sciences
Education
- Postdoctoral Fellowship: BC Children's Hospital Research Institute, 2010
- PhD: Pathology and Laboratory Medicine, University of British Columbia, 2006
Publications
- Tala Curry-Koski, Mary E. Barrameda, Theresa Currier Thomas & Mitra Esfandiarei (2024). In vivo phenotypic vascular dysfunction extends beyond the aorta in a mouse model of fibrillin-1 (FBN1) mutation. Scientific Reports. Vol. 14(1), 5779., 03/2024 - Article, Refereed Journal -
- Kasey Pull, Robert Folk, Jeemin Kang, Shaley Jackson, Brikena Gusek, Mitra Esfandiarei & Nafisa M. Jadavji (2023). Impact of maternal dietary folic acid on choline dietary deficiencies on vascular function in young and middle-aged female mouse offspring after ischemic stroke. American Journal of Physiology Heart Circulatory Physiology. Vol. 325(6), 12/2023 - Article, Refereed Journal -
- Elif Seda Selamat Tierney, Sukyung Chung, Katie Jo Stauffer, Jerrid Brabender, Ronnie Thomad Collins, Robert Folk, Weidang Li, Ashlesh K Murthy, Daniel Jerome Murphy & Mitra Esfandiarei (2022). Can 10 000 Healthy Steps a Day Slow Aortic Root Dilation in Pediatric Patients With Marfan Syndrome?. Journal of American Heart Association. Vol. 11(23), e027598., 12/2022 - Article, Refereed Journal -
- Arash Y Tehrani, Zoe White, Nadia Milad, Mitra Esfandiarei, Michael A Seidman & Pascal Bernatchez (2021). Blood pressure-independent inhibition of Marfan aortic root widening by the angiotensin II receptor blocker valsartan. Physiological Reports. Vol. 9(10), e14877., 05/2021 - Article, Refereed Journal -
- Arash Y Tehrani, Jason Z Cui, T Bucky Jones, Ester Hotova, Monica Castro, Pascal Bernatchez, Cornelis van Breemen & Mitra Esfandiarei (2020). Characterization of doxycycline-mediated inhibition of Marfan syndrome-associated aortic dilation by multiphoton microscopy. Scientific Reports. Vol. 10(1), 7154., 04/2020 - Article, Refereed Journal -
- White Z, Milad Nadia, Tehrani AY, Lamothe J, Hogg JC, Esfandiarei M, Seidman M, Booth S, Hackett TL, Morissette MC & Bernatchez P (2019). Sildenafil prevents Marfan-associated emphysema and early pulmonary artery dilation in mice. Am J Pathol. Vol. 189(8), 1536-1546., 08/2019 - Article, Refereed Journal -
- Esfandiarei M, Hoxha B, Talley NA, Anderson MR, Alkhouli MF, Squire MA, Eckman DM, Babu JR, Loapschuk GD & Broderick TL (2019). Beneficial effects of resveratrol and exercise training on cardiac and aortic function and structure in the 3xTg mouse model of Alzheimer’s disease. Drug Des Devel Ther. Vol. 13, 1197-1211., 04/2019 - Article, Refereed Journal -
- Cui JZ, Lee L, Sheng X, Chu F, Gibson CP, Aydinian T, Walker DC, Sandor GGS, Bernatchez P, Tibbits GF, van Breemen C & Esfandiarei M (2019). In vivo characterization of doxycycline-mediated protection of aortic function and structure in a mouse model of Marfan syndrome-associated aortic aneurysm. Sci Rep. Vol. 9(1), 2071., 02/2019 - Article, Refereed Journal -
- Sellers S, Milad N, Chan R, Mielnik M, Jermilova U, Huang PL, de Crom R, Hirota J, Hogg JC, Sondor GG, van Breemen C, Esfandiarei M, Seidman M & Bernatchez P (2018). Inhibition of Marfan Syndrome Aortic Root Dilation by Losartan: Role of ATR1-Independent Activation of Endothelial Function. Am J Pathol. Vol. 183(3), 03/2018 - Article, Refereed Journal -
- Gibson C, Alex R, Cooper K, Cui JZ, Gaufin D, Farney M, Broderick T, van Breemen C, Vallejo-Elias J & Esfandiarei M (2017). Structural and functional effects of mild exercise on the progression of aortic aneurysm in a mouse model of Marfan syndrome. J Appl Physiol. Vol. 123(1), 147-160., 07/2017 - Article, Refereed Journal -
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Research Interests
- Aortic Aneurysm - Vascular Complications in Alzheimer's Disease - Vascular Dysfunction in Traumatic Brain Injury - Calcium Signaling - Endoplasmic Reticulum Stress Response
Research Summary
Dr. Esfandiarei’s Laboratory is interested in understanding the pathological events underlying the initiation and progression of aortic aneurysm using a genetic animal model of aortic aneurysm and in human patients. Her research also expands to investigating functional and structural changes within the wall of blood vessels that can contribute to the development of plaque formation or the severity of brain damage in well-established animal models of Alzheimer’s disease and traumatic brain injury