Contact:
University of Arizona College of Medicine - Phoenix 475 North 5th Street, Suite Room 811, Phoenix, AZ 85004
Director, Translational Cardiovascular Research Center
Professor, Tenure - Internal Medicine
Vice Dean - Research
Director, Translational Cardiovascular Research Center
Faculty
Internal Medicine; Research
Education
- Postdoctoral Fellowship: Molecular Physiology, University of Colorado Health Sciences Center, 1983
- PhD: Biochemistry, University of California, Los Angeles, 1979
Publications
- Arrieta A, Blackwood EA, Stauffer WT, Santo Domingo M, Bilal AS, Thuerauf DJ, Pentoney AN, Aivati C, Sarakki AV, Doroudgar S & Glembotski CC (2020). Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart. Journal of Biological Chemistry. Vol. 295(22), 7566-7583., 05/29/2020 - Article, Refereed Journal -
- Blackwood EA, Bilal AS, Stauffer WT, Arrieta A & Glembotski CC (2020). Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis. Cells Journal. Vol. 9(3), 602., 03/03/2020 - Article, Refereed Journal -
- Blackwood EA, Azizi K, Thuerauf DJ, Paxman RJ, Plate L, Kelly JW, Wiseman RL & Glembotski CC (2019). Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis. Nature Communications. Vol. 10(1), 187., 01/14/2019 - Article, Refereed Journal -
- Blackwood EA, Hofmann C, Santo Domingo M, Bilal AS, Sarakki A, Stauffer W, Arrieta A, Thuerauf DJ, Kolkhorst FW, Müller OJ, Jakobi T, Dieterich C, Katus HA, Doroudgar S & Glembotski CC (2019). ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the mTORC1 Activator, Rheb. Circulation Research. Vol. 124(1), 79-93., 01/04/2019 - Article, Refereed Journal -
- Jin JK, Blackwood EA, Azizi K, Thuerauf DJ, Fahem AG, Hofmann C, Kaufman RJ, Doroudgar S & Glembotski CC (2017). ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart. Circulation Research. Vol. 120(5), 862-875., 03/03/2017 - Article, Refereed Journal -
More publications from this Faculty on
Research Interests
- Translational Biomedical Research - Unfolded Protein Response - Ischemia/Reperfusion
- Hypertrophy - Heart Failure - ER Stress Response - Cardiac - ATF6
Research Summary
Dr. Glembotski’s research focuses on discovering proteostasis-based therapeutics to treat heart disease, cancer, neurodegenerative diseases and metabolic diseases. This approach is the result of our years of focusing on mechanisms of heart disease. We develop gene- and small molecule-based therapeutics targeted toward enhancing proteome integrity. Our most recent research has expanded beyond heart disease to other pathologies caused by dysregulated proteostasis.