Rayna J. Gonzales


University of Arizona College of Medicine - Phoenix ABC-1 Building 425 North 5th Street, Phoenix, AZ 85004
AZ Biomedical Collaborative 1
Associate Professor & Director, Gastrointestinal System, Metabolism, Diabetes and Obesity (GIMDO)
Associate Professor - Basic Medical Sciences
Director, Gastrointestinal System, Metabolism, Diabetes and Obesity (GIMDO)
Basic Medical Sciences


  • Postdoctoral Fellowship: Cerebrovascular Physiology, University of California - Irvine, 2005
  • PhD: Vascular Biology, University of New Mexico, School of Medicine, 1999

Representative Recent Publications

  • Li Y, Shi SX, Liu Q, Shi FD & Gonzales RJ (2020). Targeted role for S1PR in endothelial function, neuroinflammation and neurovascular dysfunction during ischemic stroke. Neurosci Lett. Vol. 735
  • Li H, Zhou X, Li Y, Ma X, Gonzales RJ, Qiu S, Shi FD & Liu Q (2019). The selective sphingosine 1-phosphate receptor 1 modulator RP101075 improves microvascular circulation after cerebrovascular thrombosis. FASEB J. Vol. 33(10), 10935-10941.
  • Jin WN, Gonzales RJ, Feng Y, Wood K, Chai Z, Dong JF, La Cava A, Shi FD & Liu Q (2018). Brain ischemia induces diversified neuroantigen-specific T-cell responses that exacerbate brain injury. Stroke. Vol. 49(6), 1471-1478.
  • Raman P, Madhavpeddi L & Gonzales RJ (2018). Palmitate induces glycosylation of cyclooxygenase-2 in primary human vascular smooth muscle cells. Am J Physiol Cell Physiol. Vol. 314(5), C545-C553.
  • Jin WN, Ducruet AF, Liu Q, Shi SX, Waters M, Zou M, Sheth KN, Gonzales RJ & Shi FD (2018). Activation of JAK/STAT3 restores NK-cell function and improves immune defense after brain ischemia. FASEB J. Vol. 32(5), 2757-2767.
Research Interests
Vascular Inflammation, Vascular Biology, Stroke , Psychiatric Disease, Neurodegenerative Diseases, Cerebrovascular Disorders, Cell signaling, Cardiovascular Diseases, Cardiovascular Biology