Contact:
University of Arizona College of Medicine - Phoenix 425 North 5th Street, Phoenix, AZ 85004
Director, Molecular Basis of Life and Disease (MBLD) Block
Associate Professor, Tenure - Basic Medical Sciences
Director, Molecular Basis of Life and Disease (MBLD) Block - Undergraduate Medical Education
Faculty
Basic Medical Sciences; Undergraduate Medical Education
Education
- Postdoctoral Fellowship: Microbiology and Immunology, Stanford University, 2002
- PhD: Microbiology and Immunology, University of Michigan, 1998
Publications
- Ke H, Han M, Kim J, Gustin KE & Yoo D (2019). Porcine Reproductive and Respiratory Syndrome Virus Nonstructural Protein 1 Beta Interacts with Nucleoporin 62 To Promote Viral Replication and Immune Evasion. J Virol. Vol. 93(14), e00469-19., 06/28/2019 - Article, Refereed Journal -
- Park N, Schweers NJ & Gustin KE (2015). Selective Removal Of FG-Repeat Domains From The Nuclear Pore Complex By Enterovirus 2Apro. J Virol. Vol. 89, 11069-79., 11/2015 - Article, Refereed Journal -
- Kotla S & Gustin KE (2015). Proteolysis of MDA5 and IPS-1 is not Required for Inhibition of the Type I IFN Response by Poliovirus. Virol J. Vol. 12, 158., 10/06/2015 - Article, Refereed Journal -
- Pathak A, Adams RH, Shah NC & Gustin KE (2013). Persistent human rhinovirus type C infection of the lower respiratory tract in a pediatric cord blood transplant recipient. Bone Marrow Transpl. Vol. 48, 747-48., 05/2013 - Article, Refereed Journal -
- Park N, Skern T & Gustin KE (2010). Specific Cleavage of the Nuclear Pore Complex Protein Nup62 by a Viral Protease. J Bio Chem. Vol. 285, 28796-805., 09/10/2010 - Article, Refereed Journal -
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Research Interests
- Virology - RNA Virus Infections - Nuclear Pore Complex - Nuclear Fuels Transport - Cell Biology - Antiviral Response
Research Summary
Dr. Gustin's research aims to understand host-pathogen interactions that occur during infections with RNA viruses, such as rhinovirus and poliovirus. In addition to enhancing our understanding of pathogenesis, we hope to gain insights into mechanisms underlying such basic cellular processes as regulation of gene expression and nucleo-cytoplasmic trafficking. Our lab utilizes a multidisciplinary approach incorporating cell and molecular biology, genetics, biochemistry and functional genomics.