Ling He

Contact:

University of Arizona College of Medicine - Phoenix 475 North 5th Street, Phoenix, AZ 85004
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Director, Section of Metabolic Diseases
Professor, Tenure - Basic Medical Sciences
Director, Section of Metabolic Diseases - Basic Medical Sciences
Faculty
Basic Medical Sciences; Basic Medical Sciences

Education

  • Postdoctoral Fellowship: Metabolism, Johns Hopkins University, School of Medicine, 2009
  • PhD: Physiology and Nutrition, University of Arkansas for Medical Sciences, 2007
  • MS: Microbiology and Immunology, Third Military Medical University, 1994
  • MD: Third Military Medical University, 1988

Publications

  • Pearah A & Ramatchandirin B, Liu T, Wolf RM, Ikeda A, Radovick S, Sesaki H, Wondisford FE, O'Rourke B, He L. (2023). Blocking AMPKαS496 phosphorylation improves mitochondrial dynamics and hyperglycemia in aging and obesity. Cell Chem Biol. Vol. 30(12), 1585-1600.e6., 12/21/2023 - Article, Refereed Journal -
  • He L (2021). Metformin and Systemic Metabolism. Trends Pharmacol Sci (Cell Press). Vol. 22(4), 868-881., 02/20/2021 - Article, Refereed Journal -
  • Wang Y & An H, Liu T, Qin C, Sesaki H, Guo S, Radovick S, Hussain M, Maheshwari A, Wondisford FE, O'Rourke B, He L (2019). Metformin Improves Mitochondrial Respiratory Activity through Activation of AMPK. Cell Rep. Vol. 29(6), 1511-1523.e5., 11/05/2019 - Article, Refereed Journal -
  • Cao J & Peng J, An H, He Q, Boronina T, Guo S, White MF, Cole PA, He L (2017). Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity. Nat Commun. Vol. 8(1), 131., 07/25/2017 - Article, Refereed Journal -
  • He L & Sabet A, Djedjos S, Miller R, Sun X, Hussain MA, Radovick S, Wondisford FE (2009). Metformin and insulin suppress hepatic gluconeogenesis through phosphorylation of CREB binding protein. Cell. Vol. 137(4), 635-646., 05/15/2009 - Article, Refereed Journal -
Research Interests
- Signal Transduction - Mitochondrial Dynamics - Metabolism in Obesity and Diabetes - Gene Regulation
Research Summary
His research focuses on glucose and lipid metabolism and the involvement of mitochondrial dynamics. Currently, his laboratory is working on (1) defining the molecular mechanisms of metformin’s effects on mitochondrial dynamics and respiration through AMPK activation; (2) investigating mechanisms leading to the paradoxical concurrence of insulin resistance and hepatic steatosis in obesity and type 2 diabetes; and (3) studying the mechanisms responsible for the mitochondrial expansion in neonates.