Melissa M. Herbst-Kralovetz

Contact:

University of Arizona College of Medicine - Phoenix 425 North 5th Street, Phoenix, AZ 85004
Director, Women's Health Research Program
Professor, Tenure - Basic Medical Sciences
Professor, N/A - Obstetrics & Gynecology
Director, Women's Health Research Program - Obstetrics & Gynecology
Faculty
Basic Medical Sciences; Obstetrics & Gynecology; Obstetrics & Gynecology

Education

  • Postdoctoral Fellowship: Mucosal Vaccine Development, Arizona State University, The Biodesign Institute, 2008
  • PhD: Experimental Pathology, University of Texas Medical Branch at Galveston, Sealy Center for Vaccine Development, 2006

Publications

  • McKenzie R, Maarsingh JD, Laniewski P & Herbst-Kralovetz MM (2021). Immunometabolic Analysis of Mobiluncus mulieris and Eggerthella sp. Reveals Novel Insights Into Their Pathogenic Contributions to the Hallmarks of Bacterial Vaginosis. Front. Cell. Infect. Microbiol., 12/23/2021 - Article, Refereed Journal -
  • Salliss ME, Farland LV, Mahnert ND & Herbst-Kralovetz MM (2021). The role of gut and genital microbiota and the estrobolome in endometriosis, infertility and chronic pelvic pain. Hum Reprod Update. Vol. 28, 92-131., 12/21/2021 - Article, Refereed Journal -
  • Laniewski P & Herbst-Kralovetz MM (2021). Bacterial vaginosis and health-associated bacteria modulate the immunometabolic landscape in 3D model of human cervix. NPJ Biofilms Microbiomes. Vol. 7, 12/13/2021 - Article, Refereed Journal -
  • Salliss ME, Maarsingh JD, Garza C, Laniewski P & Herbst-Kralovetz MM (2021). Veillonellaceae family members uniquely alter the cervicovaginal metabolic microenvironment in a human three-dimensional epithelial model. NPJ Biofilms Microbiomes. Vol. 7, 07/06/2021 - Article, Refereed Journal -
  • Laniewski P, Ilhan ZE & Herbst-Kralovetz MM (2020). The microbiome and gynaecological cancer development, prevention and therapy. Nat Rev Urol. Vol. 17, 232-250., 04/2020 - Article, Refereed Journal -
Research Interests
- Cervical Cancer - Vaginal microbiome and sexually transmitted infections - Immunology - Host-microbe interactions and 3D biomimetic modeling
Research Summary
Dr. Herbst-Kralovetz is broadly interested in understanding innate mucosal immune responses to resident bacteria, pathogens and microbial products at mucosal sites, including the female reproductive tract (FRT). Her lab is interested in studying the mucosal barrier function of the FRT and its role in host defense and maintaining mucosal homeostasis, which is widely relevant to infection, immunity, reproduction and even cancer. She has a long-standing interest in women’s health.