Sue Kim

Contact:

University of Arizona College of Medicine - Phoenix 425 North 5th Street, Phoenix, AZ 85004
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Director, Personalized Active Learning (PAL)
Associate Professor, Tenure - Basic Medical Sciences
Director, Personalized Active Learning (PAL) - Undergraduate Medical Education
Faculty
Basic Medical Sciences; Undergraduate Medical Education

Education

  • Postdoctoral Fellowship: 2004
  • PhD: Genetics, Yale University, School of Medicine, 1998

Publications

  • Peng S, Hebert LL, Eschbacher JM & Kim S (2020). Single-cell RNA sequencing of a postmenopausal normal breast tissue identifies multiple cell types that contribute to breast cancer. Cancers. Vol. 12(12), 3639-3659., 12/04/2020 - Article, Refereed Journal -
  • Hendricks WPD, Briones N, Halperin RF, Facista S, Heaton PR, Mahadevan D & Kim S (2019). PD-1-Associated Gene Expression Signature of Neoadjuvant Trastuzumab-Treated Tumors Correlates with Patient Survival in HER2-Positive Breast Cancer. Cancers. Vol. 11(10), 1566-1521., 10/15/2019 - Article, Refereed Journal -
  • Keenen MM & Kim S (2016). Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells. Breast Cancer. Vol. 8, 211-221., 11/17/2016 - Article, Refereed Journal -
  • Kim S (2015). New and emerging factors in tumorigenesis: an overview. Cancer Manag Res. Vol. 7, 225-239., 07/28/2015 - Article, Refereed Journal -
  • Byron SA, Min E, Thal TS, Tapia C, Hostetter G, Watanabe A, Azorsa D, Little TH & Kim S (2012). Attenuation of NF-kappa B by the ING4 tumor suppressor in breast cancer. PLoS One. Vol. 7(10), 10/04/2012 - Article, Refereed Journal -
  • Tapia C, Zlobec I, Schneider S, Kilic E, Guth U, Bubendorf L & Kim S (2011). Deletion of the ING4 tumor suppressor gene is prevalent in HER2-positive breast cancer. Hum Pathol. Vol. 42(7), 983-990., 07/2011 - Article, Refereed Journal -
  • Kim S, Welm AL & Bishop JM (2010). A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. Cancer Res. Vol. 70, 5155-5162., 07/15/2010 - Article, Refereed Journal -
Research Interests
- Neuroblastoma - Genes, Tumor Suppressor - Chemokine Signaling - Breast Cancer
Research Summary
We investigate tumor suppressor (TS) genes in cancer and how TS deficiencies lead to tumor formation and progression. We have characterized Inhibitor of Growth 4 (ING4) TS in breast cancer, of which deficiency is correlated with metastatic and therapy-resistant tumors. We have defined ING4 as a transcriptional regulator that plays a critical role in tumor-immune modulation and hormone response. Ongoing studies include the molecular mechanism of ING4 and TSs in neuroblastoma and lung cancer.