Associate Professor & Director, Personalized Active Learning (PAL)
Associate Professor - Basic Medical Sciences
Director, Personalized Active Learning (PAL)
Basic Medical Sciences
- Postdoctoral Fellowship: Hooper Research Foundation, 2004
- PhD: Genetics, Yale University, School of Medicine, 1998
Representative Recent Publications
- Keenen MM & Kim S (2016). Tumor suppressor ING4 inhibits estrogen receptor activity in breast cancer cells. Breast Cancer. Vol. 8, 211-221.
- Kim S (2015). New and emerging factors in tumorigenesis: an overview. Cancer Manag Res. Vol. 7, 225-239.
- Byron SA, Min E, Thal TS, Tapia C, Hostetter G, Watanabe A, Azorsa D, Little TH & Kim S (2012). Attenuation of NF-kappa B by the ING4 tumor suppressor in breast cancer. PLoS One. Vol. 7(10)
- Tapia C, Zlobec I, Schneider S, Kilic E, Guth U, Bubendorf L & Kim S (2011). Deletion of the ING4 tumor suppressor gene is prevalent in HER2-positive breast cancer. Hum Pathol. Vol. 42(7), 983-990.
- Kim S, Welm AL & Bishop JM (2010). A dominant mutant allele of the ING4 tumor suppressor found in human cancer cells exacerbates MYC-initiated mouse mammary tumorigenesis. Cancer Res. Vol. 70, 5155-5162.
Genes, Tumor Suppressor, Gene Regulation, Cancer
We investigate tumor suppressor (TS) genes in cancer and how TS deficiencies lead to tumor formation and progression. We have characterized Inhibitor of Growth 4 (ING4) TS in breast cancer, of which deficiency is correlated with metastatic and therapy-resistant tumors. We have defined ING4 as a transcriptional regulator that plays a critical role in tumor-immune modulation and hormone response. Ongoing studies include the molecular mechanism of ING4 and TSs in neuroblastoma and lung cancer.