Contact:
University of Arizona Center for Applied Nanobioscience and Medicine 475 North 5th Street, Phoenix, AZ 85004
Assistant Research Professor, Research Series
Assistant Research Professor, Research Series - Basic Medical Sciences
Faculty
Basic Medical Sciences
Education
- PhD: Biomedical Sciences, Université Montpellier 1, College of Medicine, 2013
Publications
- Lacombe J, Cretignier T, Meli L, Wijeratne EMK, Veuthey JL, Cuendet M, Gunatilaka AAL & Zenhausern F (2020). Withanolide D enhances radiosensitivity of human cancer cells by inhibiting DNA damage non-homologous end joining repair pathway. Front Oncol. Vol. 9, 1468., 01/08/2020 - Article, Refereed Journal -
- Gu J, Norquist A, Brooks C, Repin M, Mukherjee S, Lacombe J, Yang J, Brenner DJ, Amundson S & Zenhausern F (2019). Development of an integrated fingerstick blood self-collection device for radiation countermeasures. PLoS One. Vol. 14(10), 10/16/2019 - Article, Refereed Journal -
- Lacombe J, Brengues M, Mangé A, Bourgier C, Gourgou S, Pèlegrin A, Ozsahin M, Solassol J & Azria D (2019). Quantitative proteomic analysis reveals AK2 as potential biomarker for late normal tissue radiotoxicity. Radiat Oncol. Vol. 14(1), 142., 08/09/2019 - Article, Refereed Journal -
- Taraboletti A, Goudarzi M, Kabir A, Moon BH, Laiakis EC, Lacombe J, Ake P, Shoishiro S, Brenner D, Fornace AJ Jr & Zenhausern F (2019). Fabric Phase Sorptive Extraction-A Metabolomic Preprocessing Approach for Ionizing Radiation Exposure Assessment. J Proteome Res. Vol. 18(8), 3020-3031., 05/22/2019 - Article, Refereed Journal -
- Lacombe J, Sima C, Amundson S & Zenhausern F (2018). Candidate gene biodosimetry markers of exposure to external ionizing radiation in human blood: A systematic review. PLoS ONE. Vol. 13(6), 06/07/2018 - Article, Refereed Journal -
More publications from this Faculty on
Research Interests
- Radiobiology - Platform Development - Biomarkers discovery
Research Summary
Dr. Lacombe’s research program focuses on the development of platform technologies to investigate the biochemical and biophysical response of complex cellular environments to ionizing radiation (IR). The research projects involve the elaboration of human-based models including organ-on-chips or plant-based bioengineered scaffolds. Dr. Lacombe’s projects also include molecular biology and the development of point-of-care bioassays for detecting radiation dosimetry biomarkers.