Dr. Won Hee Lee, PhD head shot

Contact Info

AZ Biomedical Collaborative 1
Room Number
Assistant Professor
College of Medicine Phx Basic Medical Sciences

Lab Website


  • Postdoctoral: Cardiovascular Medicine & Radiology, Stanford University, 2011-2015.
  • PhD: Biomedical Engineering, Virginia Tech, 2007-2010.


  • Lee WH*, Chen W*, Shao N, Xiao D, Qin X, Baker N, Bae H, Shukla P, Wu H, Kodo K, Ong SG, Wu JC. (2017). Comparison of non-coding RNAs in exosomes and functional efficacy of human embryonic stem cell-versus induced pluripotent stem cell-derived cardiomyocytes. Stem Cells, 35(10):2138-2149. PMID: 28710827.
  • Lee WH, Nguyen PK, Fleischmann D, Wu JC. (2016). DNA damage-associated biomarkers in studying individual sensitivity to low-dose radiation from cardiovascular imaging. European Heart Journal, 37(40):3075-80. PMID: 27272147.
  • Lee WH*, Nguyen P*, Hu S, Liang G, Ong S, Han L, Sanchez-Freire V, Lee AS, Vasanawala M, Segall G, Wu JC. (2015). Variable activation of DNA damage response pathways in patients undergoing SPECT myocardial perfusion imaging. Circulation Cardiovascular Imaging, 8(2):e002851. PMID: 25609688.
  • Ong S*, Lee WH*, Huang M*, Dey D, Sanchez-Freire V, Kodo K, Gold JD, and Wu JC. (2014). Cross talk of combined gene and cell therapy in ischemic heart disease: role of exosomal microRNA transfer. Circulation, 130(11 Suppl 1):S60-69. PMID: 25200057.
  • Nguyen P*, Lee WH*, Li YF, Hong WX, Hu S, Chan CK, Liang G, Nguyen I, Ong SG, Churko J, Wang J, Altman R, Fleishmann D, Wu JC. (2015). Assessment of the Radiation Effects of Cardiac Computed Tomographic Angiography Using Protein and Genetic Biomarkers. Journal of the American College of Cardiology Cardiovascular Imaging, 8(8):873-84. PMID: 26210695. (Accompanied Editorial).

*Denotes co-first authors

Research Interests

Induced pluripotent stem cells (iPSCs), Cardiovascular disease modeling, environmental toxicology

Research Summary

The Lee lab focuses on the use of human induced pluripotent stem cells to study the interplay between environmental exposure and the development of cardiovascular diseases. We seek to achieve this understanding by various cellular, genetic and biochemical approaches coupled with patients’ data. A recent focus of our research is to develop a cellular model of human origin to assess potential cardiovascular susceptibility associated with the use of e-cigarettes.