Associate Research Professor, Research Series
Associate Research Professor, Research Series - Basic Medical Sciences
Associate Research Professor, Research Series - Translational Neurosciences
Faculty
Basic Medical Sciences; Translational Neurosciences
Education
- Postdoctoral Fellowship: Neuroscience, Johns Hopkins University, 2004
- PhD: Physiology, University of Toronto, 1999
Publications
- Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, Petrucelli L, Van Keuren-Jensen K & Sattler R (2019). ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathol. Vol. 138(8), 49-65., 07/2019 - Article, Refereed Journal -
- Manzo E, Lorenzini I, Barrameda D, O'Conner AG, Barrows JM, Starr A, Kovalik T, Rabichow BE, Lehmkuhl EM, Shreiner DD, Joardar A, Liévens JC, Bowser R, Sattler R & Zarnescu DC (2019). Glycolysis upregulation is neuroprotective as a compensatory mechanism in ALS. Elife. Vol. 8, 45114., 06/10/2019 - Article, Refereed Journal -
- Xu W, Bao P, Jiang X, Wang H, Qin M, Wang R, Wang T, Yang Y, Lorenzini I, Liao L, Sattler R & Xu J (2019). Reactivation of nonsense-mediated mRNA decay protects against C9orf72 dipeptide-repeat neurotoxicity. Brain. Vol. 142(5), 1349-1364., 05/01/2019 - Article, Refereed Journal -
- Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, Suk JS, Bergles DE, Haughey N, Pletnikov M, Hanes J & Rothstein JD (2019). Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nat Neurosci. Vol. 22(5), 741-752., 05/2019 - Article, Refereed Journal -
- Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, Cairns NJ, Boylan KB, Dickson DW, Rademaker, Zhang YJ, Petrucelli L, Sattler R, Zarnescu DC, Glass JD & Rossoll W (2018). TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nat Neurosci. Vol. 21(2), 228-239., 02/2018 - Article, Refereed Journal -
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Research Interests
- Neurodegenerative Diseases - Induced pluripotent stem cells (iPSCs) - Amyotrophic Lateral Sclerosis
Research Summary
The Sattler laboratory studies cellular and molecular mechanisms of neurodegeneration in CNS disorders including amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) with a particular interest in the role of synaptic dysfunction. We utilize different disease models including patient-derived human induced pluripotent stem cells, patient autopsy brain tissue and animal models of disease and employ state of the art molecular, biochemical and microscopy technologies.