- Postdoctoral: Tumor Dormancy and Therapy Resistance, State University of New York – Albany, 2004 – 2008.
- PhD: Albany Medical College, 2002.
- Rausch MP, Sertil AR. A stressful microenvironment: opposing effects of the endoplasmic reticulum stress response in the suppression and enhancement of adaptive tumor immunity. Int Rev Immunol. 2015 Mar; 34(2):104-22.
- McCarthy DA, Ranganathan AC, Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N, Melendez JA. Redox-control of the alarmin, Interleukin-1α. Redox Biol. 2013 Apr 17;1:218-25
- Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC, Wen HC, Kapoor A, Bernstein E, Aguirre-Ghiso JA. Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One. 2012;7(1):e29974.
- Adam AP, George A, Schewe D, Paloma Bragado, Iglesias BV, Ranganathan AC, Kourtidis A, Conklin DS and Aguirre-Ghiso JA. Computational identification of a p38SAPK regulated transcription factor network required for tumor cell quiescence. Cancer Res 2009 Jul 15;69(14):5664-72
- Ranganathan AC, Ojha S, Kourtidis A, Conklin DS and Aguirre-Ghiso JA. Dual function of PERK in tumor cell survival and growth arrest. Cancer Res 2008 May 1;68(9):3260-8.
For a complete listing of Dr. Sertil's publications, search PubMed.
Cancer, ER stress, microenvironment
My research is focused on elucidating the molecular mechanisms by which cues from the tumor microenvironment utilize the ER stress response and mTOR signaling to regulate tumor initiating “stem-cell” plasticity and tumor initiation; promote therapy resistance; and force actively proliferating tumor cells to enter dormancy. This will be important to both advance our understanding of tumorigenesis and metastasis, as well as identify new targets for development of therapeutics.