Assistant Research Professor, Research Series
Assistant Research Professor, Research Series - Basic Medical Sciences
Faculty
Basic Medical Sciences
Education
- Postdoctoral Fellowship: Tumor Dormancy, GeNYSiS Center for Excellence in Cancer Genomics, 2008
- PhD: Biochemistry and Molecular Biology, Albany Medical College, Center for Immunology and Microbial Disease, 2002
Publications
- Roberts RD, Lizardo MM, Reed DR, Hingorani P, Glover J, Allen-Rhoades W, Fan T, Khanna C, Sweet-Cordero EA, Cash T, Bishop MW, Hegde M, Sertil AR, Koelsche C, Mirabello L, Malkin D, Sorensen PH, Meltzer PS, Janeway KA, Gorlick R & Crompton BD (2019). Provocative questions in osteosarcoma basic and translational biology: A report from the Children's Oncology Group. Cancer. Vol. 125(20), 3514-3525., 10/15/2019 - Article, Refereed Journal -
- Yarapureddy S, Abril J, Foote J, Kumar S, Asad O, Sharath V, Faraj J, Daniel D, Dickman P, White-Collins A, Hingorani P & Sertil AR (2019). ATF6α Activation Enhances Survival against Chemotherapy and Serves as a Prognostic Indicator in Osteosarcoma. Neoplasia. Vol. 21(6), 516-532., 06/2019 - Article, Refereed Journal -
- Rausch MP & Sertil AR (2015). A stressful microenvironment: opposing effects of the endoplasmic reticulum stress response in the suppression and enhancement of adaptive tumor immunity. Int Rev Immunol. Vol. 34(2), 104-122., 03/2015 - Article, Refereed Journal -
- McCarthy DA, Ranganathan AC (Sertil AR), Subbaram S, Flaherty NL, Patel N, Trebak M, Hempel N & Melendez JA (2013). Redox-control of the alarmin, Interleukin-1α. Redox Biol. Vol. 1, 218-225., 04/17/2013 - Article, Refereed Journal -
- Bragado P, Estrada Y, Sosa MS, Avivar-Valderas A, Cannan D, Genden E, Teng M, Ranganathan AC (Setil AR), Wen HC, Kapoor A, Bernstein E & Aguirre-Ghiso JA (2012). Analysis of marker-defined HNSCC subpopulations reveals a dynamic regulation of tumor initiating properties. PLoS One. Vol. 7(1), 29974., 01/2012 - Article, Refereed Journal -
More publications from this Faculty on
Research Interests
- mTOR Signaling - ER Stress Response - Cancer
Research Summary
Dr. Sertil's research is focused on elucidating the molecular mechanisms by which cues from the tumor microenvironment utilize the ER stress response and mTOR signaling to regulate tumor initiating “stem-cell” plasticity and tumor initiation; promote therapy resistance; and force actively proliferating tumor cells to enter dormancy. This will be important to both advance our understanding of tumorigenesis and metastasis, as well as identify new targets for development of therapeutics.