Shalini Sharma

Contact:

University of Arizona College of Medicine - Phoenix 425 North 5th Street, Phoenix, AZ 85004
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Associate Professor, Tenure
Associate Professor, Tenure - Basic Medical Sciences
Faculty
Basic Medical Sciences

Education

  • Postdoctoral Fellowship: Regulation of Pre-mRNA Splicing, 2010
  • PhD: Biochemistry, Indian Institute of Science, 1998

Publications

  • de Vries T, Martelly W, Campagne S, Sabath K, Sarnowski CP, Wong J, Leitner A, Stefanie Jonas S, Sharma S & Allain F H-T (2022). Sequence-specific RNA recognition by an RGG motif connects U1 and U2 snRNP for spliceosome assembly. PNAS. Vol. 119, 02/08/2022 - Article, Refereed Journal -
  • Martelly W, Fellows B, Kang P, Vashist A, Wohlschlegel J & Sharma S (2021). Synergistic roles for U1 snRNA stem-loops in human spliceosome assembly. RNA Biology. Vol. 18, 2576-2593 ., 12/2021 - Article, Refereed Journal -
  • Bapat A, , , , , Sertil A, and Sharma S , Schippel N, Shi X, Jasbi P, Gu H, Kala M, Sertil A & Sharma S (2021). Hypoxia promotes erythroid differentiation through the development of progenitors and proerythroblasts. Exp. Hem. Vol. 97, 32-46., 02/12/2021 - Article, Refereed Journal -
  • Martelly W, Fellows B, Senior K, Marlowe T & Sharma S (2019). ) Identification of a non-canonical RNA binding domain in the U2 snRNP protein SF3A1. RNA. Vol. 11, 1509-1521., 11/25/2019 - Article, Refereed Journal -
  • Bapat A, Keita N, Martelly W, Kang P, Seet C, Stoilov P, Jacobsen JR, Hu C, Crooks GM & Sharma S (2018). Myeloid disease mutations of splicing factor SRSF2 cause G2-M arrest and skewed differentiation of human hematopoietic stem and progenitor cells. Stem Cells. Vol. 36, 1663-1675., 11/2018 - Article, Refereed Journal -
Research Interests
- Myeloid Malignancies - Hematopoiesis - Pre-mRNA splicing
Research Summary
We are interested in understanding splicing mechanisms that regulate the formation of mature mRNA and the role of splicing factor mutations in the pathogenesis of myeloid malignancies, including acute myeloid leukemia, myelodysplastic syndrome and chronic myelomonocytic leukemia. Our goal is to identify key regulatory steps in the process of spliceosome assembly and develop targeted therapies to improve the lives of individuals with myeloid malignancies.