Metabolism in the Southwest Seminar Series

Complimentary lunch will be provided for all who register by October 17

Presenter

Dr. Cole's research involves the chemical biology of protein post-translational modifications (PTMs) in the context of signaling, epigenetics, and cancer. His lab develops and applies chemical approaches including protein semi synthesis and small molecule probes to the study of protein phosphorylation, acetylation, ubiquitination, and other PTMs in enzymes and cellular networks.

In this seminar, Dr. Cole will discuss his group’s research on the PI3-kinase/Akt signaling pathway. In particular, he will speak about how the critical protein kinase Akt is regulated by C-terminal phosphorylation. He will also describe insights into how Akt is targeted by the key kinase complex mTORC2. Dr. Cole will also summarize recent work about the catalytic mechanisms of NEDD4-family ubiquitin E3 ligases which can regulate the lipid phosphatase PTEN.

Seminar Title

• AKTivation Mechanisms

Learning Objectives

1. Understand how protein kinase Akt can be regulated by C-terminal phosphorylation
2. Recognize how mTORC2 complex targets Akt
3. Appreciate the catalytic plasticity of HECT ubiquitin ligases.

This seminar series is offered in a hybrid format and can be attended in person at the Biomedical Sciences Partnership Building (BSPB), Room E112, or virtually via Zoom. For any questions, please contact Cyndi at @email. Please visit our Metabolism in the Southwest Seminar page to view upcoming events in the series.