Translational Cardiovascular Research Center Monthly Seminar Series

The University of Arizona College of Medicine – Phoenix Translational Cardiovascular Research Center (TCRC) presents this monthly seminar series, which will cover diverse topics in Translational Cardiovascular research.

Presenter

Seminar Title

• Circadian Control of Histone Turnover During Cardiac Development and Growth

The molecular clock operates at the cell and organ level, underpinned by a subcellular network of transcriptional and protein circuits. Circadian rhythms participate in heart disease: altered circadian biology is associated with cardiac arrythmias, myocardial infarction, hypertension, and diabetes. Clock and Bmal1 are basic helix-loop-helix transcription factors that promote transcription of a set of “clock-controlled” genes, including Cryptochrome and Period. In addition to transcriptional cycling, many intermediate steps controlling protein abundance have been shown to oscillate, including splicing, mRNA degradation, translation, protein degradation, and, more recently, nucleosome deposition on chromatin. Our recent work supports the notion that α-adrenergic signaling, a critical driver of cardiac growth and contractility, is an initiating stimulus of histone turnover-dependent transcriptional remodeling of clock-controlled genes critical to myocyte hypertrophy. In our ongoing work, we seek to understand whether and how the circadian clock orchestrates early neonatal myocyte maturation, including the transition from hyperplastic to hypertrophic growth and exit from the cell cycle, by remodeling chromatin.

Faculty Hosts

• Christopher Glembotski, PhD, professor of Internal Medicine and director of the TCRC.
• Shirin Doroudgar, PhD, assistant professor of Internal Medicine and inaugural member of the TCRC.

For additional information, please contact Tina Allen, administrative assistant for the TCRC, 602-827-3240. This seminar will be hybrid.

• Location: Health Sciences Education Building, room C401 — 435 N. 5th Street, Phoenix, AZ 85004 — or join virtually via Zoom.