Translational Cardiovascular Research Center Monthly Seminar Series

The University of Arizona College of Medicine – Phoenix Translational Cardiovascular Research Center (TCRC) presents this monthly seminar series, which will cover diverse topics in Translational Cardiovascular research.

Presenter

Seminar Title

• Alternative Splicing of MYBPC3 in Hypertrophic Cardiomyopathy

Hypertrophic Cardiomyopathy (HCM) is a common genetic heart disorder frequently associated with mutations in the MYBPC3 gene, which encodes cardiac myosin-binding protein C (cMyBP-C). Alternative splicing of MYBPC3 can produce multiple isoforms, aKecting cMyBP-C’s structural and functional properties in cardiomyocytes and contributing to HCM. Aberrant splicing events may exacerbate HCM phenotypes by altering protein stability, phosphorylation, and sarcomeric integration, thereby driving maladaptive myocardial hypertrophy. Ongoing studies with Dr. Sadayappan investigate the role of MYBPC3 alternative splicing in HCM pathogenesis, underscoring the therapeutic potential of modulating splicing mechanisms to restore normal cMyBP-C function and improve cardiac outcomes in HCM patients.

In this seminar, Dr. Zhang will cover the role of hepatic activating transcription factor 3 (ATF3) in regulating lipid and lipoprotein metabolism, atherosclerosis, and fatty liver disease. He will also elaborate on the role of adipocyte ATF3 in protection against fatty liver disease. 

Faculty Host

• Christopher Glembotski, PhD, professor of Internal Medicine and director of the TCRC.

For additional information, please contact Tina Allen, administrative assistant for the TCRC, 602-827-3240. This seminar will be hybrid.

• Location: Health Sciences Education Building, room C401 — 435 N. 5th Street, Phoenix, AZ 85004 — or join virtually via Zoom.