Translational Cardiovascular Research Center Monthly Seminar Series

The University of Arizona College of Medicine – Phoenix Translational Cardiovascular Research Center (TCRC) presents this monthly seminar series, which will cover diverse topics in Translational Cardiovascular research.

Presenter

Seminar Title

• Receptor-mediated Approaches to Reducing Cardiovascular Risk

Atherosclerosis, a major cause of cardiovascular disease (CVD), is an inflammatory disease resulting from the build-up of cholesterol in plaque along the artery walls. As such, the development of strategies to lower plasma cholesterol levels remains a high priority.

While various lipid-lowering therapies designed to prevent cholesterol from accumulating in the blood have proved successful, such treatments are sometimes accompanied by adverse side effects and residual CVD risk.

In this seminar, we will discuss three different receptor-based approaches to reducing plasma cholesterol and CVD risk. At the level of the macrophage, we will focus on the roles of CD36 (an oxidized LDL receptor) and free fatty acid receptor 4 (FFAR4) in the development of atherosclerosis. We will also discuss SR-BI, a receptor responsible for mediating HDLcholesterol delivery to the liver for whole-body cholesterol excretion.

Faculty Hosts

• Christopher Glembotski, PhD, professor of Internal Medicine and director of the TCRC.
• Shirin Doroudgar, PhD, assistant professor of Internal Medicine and inaugural member of the TCRC.

For additional information, please contact Tina Allen, administrative assistant for the TCRC, 602-827-3240. This seminar will be hybrid.

• Location: Health Sciences Education Building, room C401 — 435 N. 5th Street, Phoenix, AZ 85004 — or join virtually via Zoom.