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Professor Emeritus, N/A
Professor Emeritus, N/A - Basic Medical Sciences
Faculty
Basic Medical Sciences
Education
- Postdoctoral Fellowship: University of Pennsylvania, School of Medicine, 1970
- PhD: Biochemistry, University of California, Riverside, 1968
Publications
- Haussler MR, Livingston S, Sabir ZL, Haussler CA & Jurutka PW (2021). . Vitamin D receptor mediates a myriad of biological actions dependent on its 1,25-dihydroxyvitamin D ligand: distinct regulatory themes revealed by induction of Klotho and fibroblast growth factor-23. JBMR Plus. Vol. 5, 01/27/2021 - Article, Refereed Journal -
- Livingston S, Mallick S, Lucas DA, Sabir MS, Sabir ZL, Purdin H, Nidamanuri S, Haussler CA, Haussler MR & Jurutka PW (2020). Pomegranate derivative urolithin A enhances vitamin D receptor signaling to amplify serotonin-related gene induction by 1,25-dihydroxyvitamin D. Biochemistry and Biophysics Reports. Vol. 24, 12/2020 - Article, Refereed Journal -
- Sabir MS , Haussler MR, Mallick S, Kaneko I, Haussler CA, Whitfield GK & Jurutka PW (2018). Optimal vitamin D spurs serotonin: 1,25-dihydroxyvitamin D represses serotonin reuptake transport (SERT) and degradation (MAO-A) gene expression in cultured rat serotonergic neurons. Genes and Nutrition. Vol. 13, 12/2018 - Article, Refereed Journal -
- Sabir MS, Khan Z, Hu C, Galligan MA, Dussik CM, Mallick S, Dampf Stone A, Batie SF, Jacobs ET, Whitfield GK, Haussler MR, Heck MC & Jurutka PW (2017). SIRT1 enzymatically potentiates 1,25-dihydroxyvitamin D3 signaling via vitamin D receptor deacetylation. J. Steroid Biochem. Mol. Biol. Vol. 172, 117-129., 09/2017 - Article, Refereed Journal -
- Haussler MR, Whitfield GK, Haussler CA, Sabir MS, Khan Z, Sandoval R & Jurutka PW (2016). Haussler MR, Whitfield GK, Haussler CA, Sabir MS, Khan Z, Sandoval R, and Jurutka PW. 1,25-Dihydroxyvitamin D and klotho: a tale of two renal hormones coming of age. Vitamins and Hormones. Vol. 100, 165-230., 01/2016 - Article, Refereed Journal -
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Research Interests
- Vitamin D - Nuclear Receptor - Healthy Aging
Research Summary
We study how vitamin D, via the vitamin D receptor (VDR), decelerates chronic diseases of aging, such as osteoporosis and neurodegeneration. We hypothesize that 1,25-dihydroxyvitamin D (1,25D), through regulation of a novel bone-initiated FGF23/klotho/phosphate/CYP24A1 axis, prevents hyperphosphatemia and excessive concentrations of 1,25D, slowing the onset of ectopic calcification, fibrosis, and vascular disease that can lead to kidney failure, myocardial infarction, and ischemic stroke.